NSE has been shown to exhibit neurotrophic activity in controlling neuronal survival, differentiation, and neurite regeneration of human neuroblastoma SH-SY5Y cells via activation of the phosphoinositide 3-kinase (PI3K)/Akt and MAPK/ERK signaling pathways, which regulate cytoskeleton reorganization and transcriptional factor activation in promotion of cell survival and neurite outgrowth[1]. This evidence concerns the gene ENO2 and neuroblastoma.