Due to its specific location in neurons and neuroendocrine cells and its upregulated secretion following axonal damage, NSE has been implicated as a biomarker of functional damage to neurons in SCI and several other pathophysiological conditions: traumatic brain injury, stroke, ischemia-reperfusion injury, cardiac arrest, neuroblastoma, small-cell lung cancer, and Alzheimer’s disease (AD)[2–5]. This evidence concerns the gene ENO2 and Alzheimer disease.