To evaluate whether B7-H3 was important in T cell differentiation, we measured serum concentrations of cytokines TNF-α, IFN-γ, IL-4, IL-6, and IL-10 and found no significant correlation between sB7-H3 expression of SLE patients in inactive phase and the above serum cytokine profile. Here, CD276 is linked to systemic lupus erythematosus.