As shown in Table 1, no significant difference was observed in age (P = 0.140), histological type (P = 0.508), histological grade (P = 0.490), tumor size (P = 0.770), lymph node metastasis (P = 0.761), status of ER (P = 0.724), PR (P = 0.793), HER2 (P = 1.000), and Ki-67 expression (P = 0.554) between HPV-positive and HPV-negative cancers. Here, ESR1 is linked to cancer.