Rehm et al. investigated patients who underwent abdominal aortic aneurysm repair without cardiopulmonary bypass and who had infrarenal total ischemia and found a 15-fold increase in the median syndecan-1 concentration 15 min after declamping and a slow 2-fold increase in HS after surgery. The gene discussed is SDC1; the disease is abdominal aortic aneurysm.