For instance (i) acetylation is accompanied by a decrease of HSP60 levels and functions such as interaction with p53, and re-instauration of senescence in tumor cells; (ii) acetylation and ubiquitination most likely leads to HSP60 degradation in the proteasome; and (iii) HSP60 nitration affects its trafficking, favoring its translocation into exosomes and subsequent secretion into the circulation, a situation that allows HSP60 to reach target cells, near or far, and thus exercise, for instance, a regulatory action on the immune system. Here, HSPD1 is linked to neoplasm.