PTPN2 and rheumatoid arthritis: As shown in Figure 3, Out of 4 SNPs specific to PTPN2, rs478582 was significant in RA since heterozygous (TC) or minor (CC) alleles were detected in 55/70 (78.6%) RA samples compared to 36/60 (60.0%) healthy controls (p-value ≤ 0.05, Figure 3A).