To evaluate the effect of PTPN2:rs478582 and/or PTPN22:rs2476601 on T-cell function, we treated purified T-cells from RA (N = 25) and healthy controls (N = 15) with PHA and MAP PPD-like and measured T-cell proliferative response (Figure 4). This evidence concerns the gene PTPN22 and rheumatoid arthritis.