In addition, subcutaneous implantation of TSP-1-soaked sponges increased levels of active TGF-β and induced fibroblast migration.75 Overexpression of TSP-1 in scleroderma and in keloids induces increased TGF-β activity.76–78 All these data validate the involvement of TSP-1-induced TGF-β activation in dermal wound healing and sclerosis. Here, THBS1 is linked to scleroderma.