IGKV4-1 and Hepatic fibrosis: Deletion of β6 integrin has been reported to protect mice from bile duct ligation-induced hepatic fibrosis,104 whereas global deletion of β3, β5, or β6 integrins or the conditional deletion of β8 integrins in hepatic stellate cells cannot protect mice from carbon tetrachloride-induced hepatic fibrosis.105 Because TGF-β activation in a bile duct ligation model is more likely to be contractile force-dependent, β6 anchorage to cytoskeleton is likely essential to ligand activation in the disease model, thereby conveying that β6 deletion is protective.