Owing to the inadequate recruitment of BMSC to sites of resorption, poor-quality bone is formed with unfilled resorbed areas and haphazard sclerotic areas.8 This theory has also been expanded to explain the pathogenesis of osteoarthritis, in which enhanced osteoclastic bone resorption caused by joint instability results in the release of excessive TGF-β1. Here, TGFB1 is linked to osteoarthritis.