TGFB1 and pulmonary fibrosis: Consistent with the ability of β6 integrin to activate latent TGF-β and the pro-fibrotic effects of TGF-β, 86 in the mouse model of pulmonary fibrosis induced by belomycin, wild-type mice develop pulmonary inflammation with subsequent fibrosis, whereas integrin β6–/– mice show a minor fibrotic response in response to bleomycin.39 Moreover, TGF-β-targeted genes in the lungs of integrin β6–/–mice are not significantly induced by bleomycin compared to wild-type mice.