De Boer et al. [32] in Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group also reported a positive relationship between hyperglycemia and the incidence of HTN in T1D, and intensive insulin therapy reduces the long-term risk of developing HTN. The gene discussed is INS; the disease is type 1 diabetes mellitus.