AOPEP and ischemia: We therefore studied apo-sGC activator treatment over time (during 4 h) to compare the effects on systemic blood pressure vs. relative regional cerebral blood flow (rCBF) in the territory of the right middle cerebral artery as measured by Laser Doppler Flowmetry.27 Importantly, no differences in baseline rCBF (100% before ischemia) nor immediately after ischemia (insertion of the occluding filament) were observed, indicating comparable procedural conditions in both groups.