ARNT and breast carcinoma: In the rs7701292 locus, the minor allele was found to associate with decreased expression of RAB9P1. Rs1712662, a tag SNP for rs7701292 (r2 = 0.79 D’ = 1), disrupts a binding motif for HIF-1β, a regulator of RAB9P1 in the ER-positive MCF-7 breast cancer cell line [13].