Although anti-PD1/PD-L1 antibodies caused few chemotherapy-related adverse events, the immune-mediated adverse events, including inflammatory pneumonitis, interstitial nephritis, hyperthyroidism, and hypothyroidism, occurred more frequently in pulmonary, endocrine, mucocutaneous and renal sites and even immunologically privileged sites such as the eye. The gene discussed is CD274; the disease is interstitial nephritis.