Importantly, Akt activation may promotes glucose utilization to provide energy for cell proliferation and facilitate energy metabolism and cell survival [27, 28], and could potentially increase VEGF production because Akt signaling induces tumor angiogenesis by regulating VEGF via both hypoxia-inducible factor (HIF)-dependent and -independent mechanisms [29, 30]. This evidence concerns the gene AKT1 and neoplasm.