CD274 and nonpapillary renal cell carcinoma: In order to understand the role of IFN-lambda3 in more detail, it would be necessary to examine the relationship of IFN-lambda3 polymorphisms with IFN-lambda3 mRNA and protein levels, and the direct association of between IFN-lambda3 polymorphism with increased PD-L1 or pAkt(Ser-473) expression in ccRCC patients.