Matched analysis of Cks1 expression in primary and metastatic melanomas from the same patients (n = 22) showed higher nuclear Cks1 labeling index in metastatic lesions in 13 cases, lower in 6 cases and similar expression in 4 cases (n = 23; in analyzed cohort one patient had two metastatic lesions evaluated by immunohistochemistry). Here, CKS1B is linked to metastatic melanoma.