To date, three c-FLIP isoforms -c-FLIP-long (c-FLIPL), c-FLIP-short (c-FLIPS), and c-FLIPR - have been recognized at the protein level [12–14], and elevated expression of both c-FLIPL and c-FLIPS isoforms were reported in some lung cancers [15]. The gene discussed is CFLAR; the disease is lung cancer.