Of these c-Cbl [24–26], c-Raf [24, 27–29], Lyn [24, 28], VAV1 [26, 37, 54], and CD38 [26] have been found partnered in a signalsome that generates a signal that regulates proliferation/differentiation and propels RA-induced differentiation of HL-60 AML cells. The gene discussed is CBL; the disease is acute myeloid leukemia.