Predicated on the emerging significance of the c-Cbl-centered signalsome, we interrogated de novo non-APL AML samples that were either untreated or treated with RA alone or in combination with F or B, which are ligands for signalsome AhR and SFK, for cell surface markers that have been used as indexes of differentiation/stemness and have been attributed with signaling capabilities governing proliferation/differentiation. Here, CBL is linked to acute promyelocytic leukemia.