Importantly, when we combined the expression of HLA-I and PD-L1 we found that the phenotypes with the highest degree of tumor infiltration with CD8+ T-cells were HLA+/PDL+ and HLA+/PDL1–, while HLA–/PDL+ tumors almost did not have any intratumoral lymphocytes (Figure 4). This evidence concerns the gene CD8A and neoplasm.