Thus, HLA-I expression appeared to be an important factor associated with primary tumor size (T) in PD-L1-positive tumors: the majority of HLA-I–/PD-L1+ tumors had larger tumor size (T3+T4), as compared to HLA-I+/PD-L1+ tumors (p < 0.023) and HLA-I–/PD-L1- tumors (p < 0.008) (Table 3). The gene discussed is CD274; the disease is neoplasm.