CD8A and neoplasm: Interestingly, in tumors with heterogeneous HLA-I expression we were also able to see such an HLA-I-dependent distribution of CD8+ T-lymphocytes (Figure 1), where TILs can be seen only in HLA-I-positive tumor nests, while in HLA-I negative areas tumor-infiltrating cells are restricted only to the stromal area in the tumor margin.