Although this negatively impacts the value of survivin for the immunotherapy of myeloid leukemia, it’s epitopes have been characterised for immunotherapy (recently reviewed in [26]) and are likely to be useful in the generation of anti-tumor responses that may lead to epitope spreading and, at the least, could elongate the remission period and enable the administration of LSC-targeting treatments. This evidence concerns the gene BIRC5 and neoplasm.