HOTAIR and breast cancer: In one study concerning HOTAIR polymorphisms and breast cancer [51], the rs1899663 T allele also did not show significant differences in the frequency distribution of cancer patients and healthy controls in an overall correlation analysis, while the follow-up stratified analysis indicated the GT+TT genotypes had a significantly lower risk of BC among women with age at menarche >14 (OR = 0.42, 95% CI = 0.21–0.82) and number of pregnancies >2 (OR = 0.65, 95% CI = 0.49–0.95).