Both PLK1 (Figure 4A) and HRAS (Figure 4B) were found to be strongly upregulated in HCC as compared to non-HCC liver tissues in several patient datasets (Chen Liver, 197 patient samples [33]; Wurmbach Liver, 75 patient samples [34]; Roessler Liver, 43 patient samples [35]). This evidence concerns the gene PLK1 and hepatocellular carcinoma.