CD38 and HLA-DR expression was observed in circulating CD8+ T cells of SS patients and was associated with high serum levels of sCD38, suggesting heightened immune activation in SS patients. During chronic viral infections, such as HIV, increased CD38 expression in CD8+ T cells is correlated with disease progression [19] and offers an additional independent predictive value for evaluating plasma viral loads and CD4+ T cell counts [22]. This evidence concerns the gene CD8A and synovial sarcoma.