We also show that ZNF224 repression on c-Myc in CML results in a decreased proliferation and c-Myc proliferative network, leading to a decreased cyclin D1 expression, a positive c-Myc target gene [36], and an increased p21 expression, a negative c-Myc target gene [37–42]. The gene discussed is CCND1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.