WT1 and chronic myelogenous leukemia, BCR-ABL1 positive: However, since WT1 transcription factor also plays a role in c-Myc transcriptional regulation in CML [35], we cannot exclude that ZNF224 could downmodulate c-Myc also by acting as a WT1 transcriptional cofactor and by suppressing WT1-mediated transactivation of c-Myc gene in CML, as already demonstrated for other WT1 target genes [23, 24].