It has been previously demonstrated by Xie et al. [16] that Bcr-Abl-mediated induction of c-Myc expression is dependent on activated JAK2 tyrosine kinase, that plays a key role in the stabilization of c-Myc protein and in the induction of c-Myc mRNA transcription in CML, although the molecular mechanisms of this induction have not been clarified. The gene discussed is JAK2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.