In accordance with the key role of c-Myc reduction in Imatinib responsiveness [12, 13] and with the already described pro-apoptotic mechanisms driven by ZNF224 in CML cells, ZNF224 knockdown led to an impairment of Imatinib-induced cell death. Here, MYC is linked to chronic myelogenous leukemia, BCR-ABL1 positive.