However, we cannot rule out that ZNF224 induction also plays a role in the Imatinib-mediated proliferative arrest, as already described for THAP11, another important transcriptional repressor of c-Myc oncogene in CML, downstream Bcr-Abl [45]. The gene discussed is ZNF224; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.