In this study, we report the hsa-miR-155-mediated Ova suppression of CD34+/CD38− CML cell viability and hCSC-like phenotype, including their associated pluripotency and survival signaling, through the dysregulation the PI3K/AKT/mTOR signaling pathway. This evidence concerns the gene PIK3CA and chronic myelogenous leukemia, BCR-ABL1 positive.