CD38 and chronic myelogenous leukemia, BCR-ABL1 positive: We found that Ova, a bioactive macrocyclic diterpenoid isolate of Anisomeles indica (L.)Kuntze, with demonstrated anti-CSCs activity in solid tumor [12, 13] exhibited significantly inhibited the viability, Bcr-Abl signaling, and hCSC-like phenotype of these CD34+/CD38− cells, and most importantly, we showed that Ova enhances the toxicity of IM across all CML cell populations, CD34+/CD38− inclusive (Figures 2 and 3).