The gene with the second highest degree (12) was Src-like-adaptor (SLA), which is expressed in a variety of cell types, and it can both inhibit and activate signaling downstream of various cell surface receptors including the B cell receptor, the T cell receptor, cytokine receptors and receptor tyrosine kinases, which are important regulators of immune and cancer cell signaling [16]. The gene discussed is CD177; the disease is cancer.