Knockdown of SLFN11 increases chemoresistance of cancer cells to a broad range of DNA damaging agents [12, 14], and ectopic expression of SLFN11 sensitizes colon cancer cells to topoisomerase I inhibitors [15], consistent with the involvement of SLFN11 in the DNA damage response [12]. This evidence concerns the gene SLFN11 and malignant colon neoplasm.