In this study, we for the first time investigated the impact of a set of HPV and such different SNPs as TP53 Arg72Pro (rs1042522), MDM2 T309G (rs2279744), MDM4 (rs4245739), MTHFR (rs1801133), CASP8 (rs3834129), and CCR5 (rs333) on the advanced LC patients` survival. Here, MDM4 is linked to laryngotracheoesophageal cleft.