Literature research data on relationship between SNPs of genes TP53c.215 G>C (Arg72Pro), MDM2c.-5 + 309 G>T, MDM4c.1q32 A>C, MTHFRc.677 C>T-652, CASP8c.6N ins/del, CCR5-Δ32 and patients with LC survival rates were highly controversial. Here, CCR5 is linked to laryngotracheoesophageal cleft.