In our study we investigated the TP53 Arg72Pro (rs1042522), MDM2 T309G (rs2279744), MDM4 (rs4245739), MTHFR (rs1801133), CASP8 (rs3834129), and CCR5 (rs333) polymorphisms in 92 Lithuanian LC patients. Here, TP53 is linked to laryngotracheoesophageal cleft.