Together, these results suggest that increased signaling in the Ras pathway, as well as other potentially oncogenic pathways [41] operating independently or in some cases together with mutant FGFR3 or other proteins regulated by HDAC6 such as EGFR [21–23], may contribute to reduced tumor growth caused by HDAC6 deficiency or inhibition. This evidence concerns the gene HDAC6 and neoplasm.