CD8A and Autoimmunity: In disaggregated human tonsil cells, ~90% of CD8+ T cells with a follicular phenotype (CXCR5+CCR7−) appear to be part of the newly described CD8+ follicular Treg subset, This subset is defined phenotypically as CD44hiCXCR5hi, and functionally by expression of IL-10, TGF-β, and Tim-3 and low levels of perforin (63) Follicular CD8+ Tregs have been demonstrated in mouse models to inhibit TFH expansion, antibody production, and autoimmunity (64, 65).