When comparing the emerging FD pain related genes with the global pain systems network for heat nociception (Neely et al., 2012) only epidermal growth factor receptor pathway substrate 8 (Eps8), alpha-N-acetylgalactosaminidase (Naga) and the proteasome subunit gene Psmb8 were contained. The gene discussed is NAGA; the disease is Fabry disease.