The E3 ubiquitin ligase Nedd4 is decreased in DRGs of SNI mice (Laedermann et al., 2013), and ribosomal protein Rps25, as well as other ribosomal proteins are downregulated in a model for HIV-associated neuropathic pain (Maratou et al., 2009). This evidence concerns the gene NEDD4 and neuropathic pain.