Interestingly, 30% of Fabry patients show cerebral microbleeds (Kono et al., 2016), which together with the downregulated Thrombospondin 1 (Thsd7a) and Thromboxane a2 receptor (Tbxa2r) can be related to a general deficit in blood coagulation pathways. Here, THSD7A is linked to cerebral microbleeds.