TRPM8 and Fabry disease: With regards to temperature sensitive ion channels it has been shown that expression of Trpv1 was increased, whereas expression of Trpm8 was decreased in skin biopsies of FD mice (Lakoma et al., 2014, 2016), which may be related to the changed thermal thresholds reported in both Fabry patients and mice (Sheth and Swick, 1980; Dutsch et al., 2002; Uceyler et al., 2013; Namer et al., 2017).