The expression levels of p53 target genes, p21 and MDM2, were evaluated in 3 ovarian cancer cell lines (IGROV-1 with WT p53, OVCAR-3 with exon 7 mutation in p53, and p53-null SK-OV-3), and 5 ovarian cancer cases (cases 16 and 17 with WT p53, case 9 with a DNA binding domain mutation and cases 11 and 15 with proline rich domain mutations). The gene discussed is TP53; the disease is ovarian cancer.