Also, the combination of IL-6 or CIC demonstrated the highest odds ratio of predicting active clinical SLE compared to the combination of complement or anti-dsDNA (OR = 7.27, 95%CI (1.99–26.63), p = 0.003 vs. OR = 3.14, 95%CI (1.16–8.48), p = 0.024) (Table 5). The gene discussed is IL6; the disease is systemic lupus erythematosus.