SGK1 and miotic rate: Since DOCA-elicited SGK1 and TGF-β expression were ameliorated in RAGE-KO mice, RAGE-apt might restore the MR-induced glomerular matrix accumulation through the suppression of SGK1 and TGF-β expression, thereby protecting damages in several renal cells including podocytes, mesangial cells, and proximal tubular cells.