Since CML accumulation in atherosclerotic plaques was diminished in RAGE-deleted ApoE-KO diabetic mice31, it is conceivable that engagement of Aldo-elicited CML to RAGE stimulates ROS production, which in turn promotes the further production of CML, thus forming a positive feedback loop between RAGE downstream signaling and CML generation. This evidence concerns the gene APOE and chronic myelogenous leukemia, BCR-ABL1 positive.