Our data revealed that co-culture with control ECs, and to a greater extent, with glioma-CM-pretreated ECs, induced robust CD206 expression: notably, over 60% of CD11b+ macrophages positively expressed CD206 when co-cultured with glioma-CM-pretreated ECs, implicating that glioma microenvironment-stimulated ECs promote alternative activation of macrophage (Fig. 2a). Here, ITGAM is linked to glioma.