EPAS1 and neuroblastoma: Interestingly, a recent work that has screened 270 transcriptional factors shows that PPARγ coactivator/estrogen-related receptor induces HIF-2α expression in neuroblastoma, independent of canonical hypoxia-mediated regulation of protein stability, but through transcription regulation65, supporting our observation of HIF-2α mRNA expression induced by PPARγ in GBM.