Moreover, when we added “increased total IgE” and “sensitization of cockroach” as separate variables in the same multivariate model, sensitization of cockroach is an independent predictor of risk of DM (OR 2.16; 95% CI, 1.21–3.84; Table 3, model 5), regardless of total IgE. The gene discussed is IGHE; the disease is diabetes mellitus.