GJB2 and neoplasm: Moreover, Cx26 overexpression in MDA-MB-231 and HCC70 non-CSCs resulted in significantly elevated tumor initiation frequency compared with empty vector (in MDA-MB-231 non-CSCs, frequency increased from 1 in 100,956 for cells transduced with empty vector compared to 1 in 14,753 for the cells overexpressing Cx26; in HCC70 non-CSCs, frequency increased from 1 in 4,031,207 for cells transduced with empty vector compared to 1 in 45,720 for the cells overexpressing Cx26; Fig. 2d and Supplementary Fig. 1e).