To investigate the role of connexins in the context of their previously reported role as tumor suppressors, we interrogated 7 different datasets containing a total of 250 normal breast samples and over 2,400 TNBC samples and found that Cx26 was the most highly expressed connexin in TNBC versus non-neoplastic mammary gland tissue (Fig. 1a). This evidence concerns the gene GJB2 and neoplasm.