However, the low LD between those signals on 8q21.11/HNF4G (PDAC-rs2941471 and BMI-rs1740581947, r2 = 0.05), 17q12/HNF1B (PDAC-rs4795218 and T2D-rs443079648, r2 = 0.0007), and 12q24.31/HNF1A (PDAC-rs7310409 and T2D-rs1242735348, r2 = 0.18) indicates that the underlying functional mechanism for the pancreatic cancer GWAS signals may differ from those for adult-onset T2D and BMI. This evidence concerns the gene HNF4G and familial pancreatic carcinoma.