We have previously shown a 3-marker host biosignature consisting of epidermal growth factor (EGF), macrophage inflammatory protein (MIP)-1β and interleukin (IL)-1α, which resulted in the correct classification of 87% of adult pulmonary TB cases and 91% of household contacts after cross validation following QuantiFERON stimulation of whole blood12. This evidence concerns the gene EGF and pulmonary tuberculosis.