Our previous studies showed that RFX1 could recruit a repressor complex including DNMT1, HDAC1, and SUV39H1 proteins and that RFX1 downregulation could lead to decreased recruitment of DNMT1, HDAC1, and SUV39H1 to the promoters of CD11a and CD70 in SLE CD4+ T cells16, 21. This evidence concerns the gene ITGAL and systemic lupus erythematosus.