However, in CD4+ T cells of patients with SLE, RFX1 expression is inhibited by IL-6-induced pSTAT3 through the regulation of the histone acetylation and DNA methylation status of intron 7 of RFX1, and RFX1 downregulation relieves the epigenetic restraint of the promoter region of IL17A, leading to the overproduction of IL-17 in SLE patients. The gene discussed is CD4; the disease is systemic lupus erythematosus.