By contrast, we found that the H3ac level was downregulated and H3K9me3 level and DNA methylation levels of several CG pairs within the IL17A promoter region were elevated in SLE CD4+ T cells transfected with an RFX1 expression plasmid compared with empty control (Fig. 4d–f). This evidence concerns the gene RFX1 and systemic lupus erythematosus.