The results showed that the H3ac level was higher and that the H3K9 me3 level and the RFX1-binding level were lower in CD4+ T cells of SLE patients compared with healthy controls, which suggests that the changed histone markers may be related to RFX1 binding in the IL17A promoter region in SLE CD4+ T cells (Supplementary Fig. 1b–d). Here, CD4 is linked to systemic lupus erythematosus.