ANGPT2 and acute respiratory distress syndrome: Fourth, although sRAGE, a marker of lung epithelial injury, may be informative to discriminate patients at higher risk of developing ARDS, the predictive value of other markers, such as Ang-2 (marker of lung endothelial injury) or markers of a hyperinflammatory phenotype (interleukin (IL)−8, tumor necrosis factor-receptor 1, bicarbonates39, and/or IL-6, interferon gamma, angiopoietin 1/2 and plasminogen activator inhibitor-140), alone or combined together, deserves further investigation.