To confirm the role of endothelial HIF-2α in mediating SOD3 effects on tumor vasculature, we analyzed the result of SOD3 overexpression on Doxo effectiveness in mice lacking HIF-2α in ECs (HIF-2αEC-KO), obtained by crossing HIF-2αf/f42 with VE-Cad-CreERT2 mice. The gene discussed is EPAS1; the disease is neoplasm.