In this study, we found that overexpression of CBX7 in gastric carcinoma cells led to increased expression of phosphorylated AKT (pAKT) and phosphorylated EKR (pERK), while knockdown of CBX7 decreased the levels of pERK and pAKT, suggesting that CBX7 can regulate AKT and EKR pathways. The gene discussed is AKT1; the disease is gastric carcinoma.