In this study, we found that overexpression of CBX7 in gastric carcinoma cells led to increased expression of phosphorylated AKT (pAKT) and phosphorylated EKR (pERK), while knockdown of CBX7 decreased the levels of pERK and pAKT, suggesting that CBX7 can regulate AKT and EKR pathways. This evidence concerns the gene CBX7 and gastric carcinoma.