Regulation of calcineurin by insulin-like growth factor I and interaction with the transcription factor FOXO3 were recently identified as prime drivers for inflammation in Alzheimer’s disease [19, 32], and blockade of calcineurin-FOXO binding decreased neuropathologies in murine models of Alzheimer’s disease [33]. The gene discussed is FOXO3; the disease is early-onset autosomal dominant Alzheimer disease.