These correspond to LRP5 (which encodes Low Density Lipoprotein Receptor-Related Protein 5) and SERPINF1 (which encodes Pigment Epithelium Derived Factor (PEDF) belonging to Serpin Peptidase Inhibitors superfamily) respectively; and both contribute to hypertension [55, 56]. The gene discussed is LRP5; the disease is Hypertension.