Our joint network analyses using miRNA and mRNA expression data have predicted a close relationship between 8 miRNAs (including miR-9, miR-490-5p, miR-490-3p, miR-182, miR-34a, miR-196b, miR-34b*, miR-181a-2*) and a 9-mRNA set (including CAV2, LAPTM4B, TIMP1, PKIG, WASF1, MMP1, ERVH-4, NME4, HSD17B12), collectively implicating distinct miRNA/mRNA subsets in an integrated network regulating the essential thrombocythemia (vide infra). This evidence concerns the gene MMP1 and essential thrombocythemia.