This is illustrated by the calcium-sensing receptor (CaSR), a class C GPCR that is widely expressed and has calcitropic roles, i.e., regulation of extracellular calcium (Ca2+e) by the parathyroids, kidneys, and bone, and non-calcitropic roles such as inflammation, bronchoconstriction, wound healing, gastro-pancreatic hormone secretion, hypertension, and glucose metabolism (Hofer et al., 2000, Rossol et al., 2012, Yarova et al., 2015, Zietek and Daniel, 2015). The gene discussed is CASR; the disease is Hypertension.