DSS‐induced colitis is the tumor‐promoting condition in the azoxymethane/dextran sulfate sodium (AOM‐DSS) model of colitis‐associated CRC (Crncec et al., 2015), and we wondered if sex‐specific STAT1 effects in colitis and CD8+ T‐cell infiltration impact tumor formation. This evidence concerns the gene STAT1 and colorectal carcinoma.