Biallelic mutations in SCYL1 wererecently identified as causing a syndromal disorder characterized by peripheralneuropathy, cerebellar atrophy, ataxia, and recurrent episodes of liver failure.The occurrence of SCYL1 deficiency among patients with previously undeterminedinfantile cholestasis or acute liver failure has not been studied; furthermore,little is known regarding the hepatic phenotype. This evidence concerns the gene SCYL1 and liver failure.