Minor febrile infectionstriggered three to five episodes of liver crises, which did not always fulfillcriteria of an ALF according to the criteria developed by the pediatric ALF study group.1 It remains unclear if the previously reported SCYL1-deficientindividuals had ALF fulfilling these criteria, as laboratory findings or assessmentof hepatic encephalopathy were not provided.17 A further, more recent case report by Smith et al.32 described another patient with SCYL1 deficiency with a pattern ofrecurrent hepatopathy—not mentioning liver failure. This evidence concerns the gene SCYL1 and liver failure.