SCYL1 and Decreased liver function: In addition to its role in intracellular trafficking, SCYL1 is thoughtto be a part of the aminoacylation-dependent nuclear tRNA export machinery.36 This is of interest as cytosolic aminoacyl-tRNA synthetasedeficiencies are associated with infantile hepatopathy and variable neurological phenotypes,7,8,9 linking SCYL1 deficiency and cytosolic aminoacyl-tRNA synthetasedeficiencies.