Su et al. (2015) demonstrated that miR-181a inhibits differentiation of HL-60 cells and CD34+ hematopoietic stem/progenitor cells by directly targeting PRKCD-P38-C/EBPα pathway [59] and Jones et al. (2015) reported that miR-215 target caudal-type homeobox 1 (CDX1) and regulates colorectal cancer stem cell differentiation [60]. The gene discussed is PRKCD; the disease is colorectal cancer.