Here, we exposed D. melanogaster larvae to S. carpocapsae symbiotic or axenic nematodes and analyzed the transcriptional regulation of PGRP-LE (Immune deficiency pathway, Imd), MyD88 (Toll pathway), Wengen (Wgn, c-Jun N-terminal kinase signaling pathway; Jnk), Domeless (Dome, Janus kinase and signal transducer and activator of transcription pathway; Jak/Stat), Dawdle (Daw, Activin branch of the transforming growth factor beta pathway; TGFβ) and Decapentaplegic (Dpp, Bone Morphogenetic Protein branch; TGFβ pathway), which belong to different immune signaling pathways. This evidence concerns the gene TGFB1 and hyperinsulinemic hypoglycemia, familial, 4.