HSPB6 and dilated cardiomyopathy: In a screening for polymorphisms associated with human dilated cardiomyopathy, it was later found that a single base change of C to T at nucleotide 59 in the N-terminus of HSP20, resulting in an amino acid substitution from proline 20 to leucine (P20L), strongly impaired PKA-mediated phosphorylation of HSP20 [89].