Contrasted with control Ldlr−/− mice, as well as Cd1d−/−Ldlr−/− mice that lack the entire complement of NKT cells, the Ja18−/−Ldlr−/− mice that lack only iNKT cells exhibited increased weight gain, hyperlipidemia, adipose tissue inflammation, as well as increased aortic atherosclerosis. This evidence concerns the gene CD1D and hyperlipidemia.