LDLR and obesity due to melanocortin 4 receptor deficiency: The feeding of an obesogenic diet (high fat, high sucrose) supplemented with additional cholesterol (HFHSC) to mice in the LDLR deficient (Ldlr−/−) background results in much more profound hyperlipidemia than in wild type mice, and enables the simultaneous evaluation of obesity and atherosclerosis [29].