TP53 and cyst: TP53 regulates the expression of vascular endothelial growth factor (VEGF); higher VEGF expression stimulates angiogenesis, ultimately promoting osteogenesis in the mandibular bones, and the newly formed bone narrows the cyst.[25] The overexpression of TP53 protein in UA may not be solely attributable to the mutation of the TP53 gene, but to defects in protein degradation.